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A new one-pot, three-component synthesis of 2,3,5-substituted or annulated 6-(methylthio)pyridines.

  作者 Yadav, A. K.;Yadav, S. K. S.;Siddiqui, I.;Peruncheralathan, S.;Ila, H.;Junjappa, H.;  
  选自 期刊  SYNLETT;  卷期  2008年-17;  页码  2674-2680  
  关联知识点  
 

[摘要]A new 1-pot, 3-component synthesis of 2,3,5-substituted (or 2,3-annulated)-6-(methylthio)pyridines by reacting acyclic or cyclic active methylene ketones, NH4OAc, and (MeS)2C:CRCHO (R = H, Ph; as C3 1,3-biselectrophiles) in the presence of either AcOH-CF3CO2H (4:1) or ZnBr2 (or ZnI2) catalysts was reported.

 
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