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Phenazines and cancer

  作者 Cimmino, A; Evidente, A; Mathieu, V; Andolfi, A; Lefranc, F; Kornienko, A; Kiss, R  
  选自 期刊  Natural Product Reports ;  卷期  2012年29-4;  页码  487-501  
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[摘要]Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.

 
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