Elaboration of Peptidomimetics Derived from a PADAM Approach: Synthesis of Polyfunctionalised 2(1H)-Pyrazinones via an Unexpected Aromatisation

[摘要]：When the PADAM (Passerini reaction-amine deprotection-acyl migration) strategy is applied to N-Boc amino acids, the resulting beta-acylamino-alpha-hydroxyamides can be elaborated by secondary-alcohol oxidation, Boc deprotection, and intramolecular cyclisation. When TFA is employed to cleave the Boc group a spontaneous aromatisation to 2(1H)-pyrazinones is observed.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内