Design and Synthesis of New Imidazolinone Derivatives as Potential Antifungal Agents

[摘要]：A new series of chalcones, pyrimidines, and imidazolinone is described; chalcones (4a-o) were prepared from the lead 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde. Pyrimidines (5a-o) were prepared from the reaction of chalcones and guanidine nitrate in alkali media. Imidazolinones (6a-o) were synthesized from the reaction of pyrimidine and oxazolone derivatives (prepared by Erlenmeyer azlactone synthesis). The structures of the synthesized compounds were assigned on the basis of elemental analyses, IR, H-1-NMR, and C-13-NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison with the standard drugs.

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