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Anti-inflammatory flavonoids from Ciyptocarya chingii

  作者 Feng, R; Guo, ZK; Yan, CM; Li, EG; Tan, RX; Ge, HM  
  选自 期刊  Phytochemistry;  卷期  2012年76-1;  页码  98-105  
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[摘要]Six flavonoids named cryptogiones A-F, and nine known compounds were isolated from an ethanol extract of stems of Cryptocarya chingii. The structures of the compounds were elucidated by interpretation of comprehensive spectroscopic data and X-ray analysis. A majority of these flavonoids contained an acetic acid/lactone moiety, a possible taxonomic marker. Anti-inflammatory effects of the compounds were evaluated using in vitro assays. At 20 mu M concentration, three compounds significantly inhibited TNF alpha-induced NF-kappa B activation and LPS-induced IL-beta expression. (C) 2012 Elsevier Ltd. All rights reserved.

 
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