[摘要]：With the emergence of the copper-catalysed Huisgen cycloaddition the use of azide- and alkyne-derivatised a-amino acids has found widespread use within most chemistry disciplines. Despite a growing interest in these building blocks researchers are struggling to identify the best way for their synthesis. In this review we have compiled available methods for synthesising optically active azide- and alkyne-derivatised a-amino acids that can be prepared from readily available a-amino acids. We highlight a number of commonly overlooked problems associated with existing methods and direct attention to unexplored possibilities. |
