[摘要]：Background. The immunogenicity of a high hemagglutinin (HA) dose or a second dose of influenza vaccine in human immunodeficiency virus (HIV)-infected individuals has not been fully explored. Methods. One hundered ninety-two HIV-infected individuals aged 18-64 years were stratified by CD4 cell count (< 200 cells/mL or >= 200 cells/mL) and randomized to receive 2 doses of 15 mu g or 30 mu g HA 2009 H1N1 vaccine 21 days apart. Hemagglutination inhibition (HAI) and microneutralization (MN) antibodies were measured on days 0, 10, 21, 31, 42, and 201. Results. Recipients of 30 mu g HA had significantly higher HAI geometric mean titers (GMTs), compared with recipients of 15 mu g HA on days 10 (139.0 vs 51.9; P = .01), 21 (106.7 vs 51.9; P = .001), and 31 (130.0 vs 73.7; P = .03) but not on days 42 (91.8 vs 61.6; P = .11) and 201 (43.0 vs 27.0; P = .08). When analyzed by CD4 cell count stratum, HAI GMTs were significantly higher among 30 mu g HA recipients than among 15 mu g HA in the CD4 cell count < 200 cells/mL stratum on days 21 and 31 and the MN GMTs on days 10, 21, 31, and 42 (P < .05). In the CD4 cell count >= 200 cells/mL stratum, MN GMTs were significantly higher among recipients of 30 mu g HA than among recipients of 15 mu g HA on day 10 (P = .03). Conclusion. Increasing the HA dose of the 2009 H1N1 vaccine improves the vaccine's immunogenicity in HIV-infected individuals.
