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Tri-, Tetra- and Pentapeptidoylbenzotriazoles: Novel Synthetic Intermediates

  作者 ABDELMAJEID ABDELMOTAAL; TALA SRINIVASA R; AMINE M S; KATRITZKY ALAN R  
  选自 期刊  Synthesis;  卷期  2011年-18;  页码  2995-3005  
  关联知识点  
 

[摘要]Conveniently synthesized novel N-(protected alpha-tri-, tetra-and pentapeptidoyl)benzotriazoles couple in aqueous acetonitrile solution at 0 degrees C with free amino acids, dipeptides, and tripeptides to afford N-terminal-protected polypeptides (61-92%) including those containing unprotected OH, SH, and indole NH groups, with no detectable racemization.

 
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