Synthesis of (R)-Coniine and (S)-Coinicine via Organocatalytic alpha-Aminoxylation of an Aldehyde

[摘要]：A short and efficient synthesis of the indolizidine alkaloid (S)-coinicine has been achieved using organocatalytic sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of an aldehyde catalyzed by L-proline. Similarly, a common organocatalytic alpha-aminoxylation route has been developed for the asymmetric synthesis of both (R)-coniine and (S)-coinicine.

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