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HRMS directly from TLC Slides. A powerful tool for rapid analysis of organic mixtures.

  作者 Smith, Natalie J.;Domin, Marek A.;Scott, Lawrence T.;  
  选自 期刊  Organic Letters;  卷期  2008年10-16;  页码  3493-3496  
  关联知识点  
 

[摘要]High-resoln. mass spectra (HRMS) of individual spots on thin-layer chromatog. (TLC) slides can now be obtained quickly and easily at atm. pressure, with zero sample prepn., using com. available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compds. of high volatility and high thermal stability. TLC-HRMS can be used to monitor chem. reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic org. chem.

 
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