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[摘要]:High-resoln. mass spectra (HRMS) of individual spots on thin-layer chromatog. (TLC) slides can now be obtained quickly and easily at atm. pressure, with zero sample prepn., using com. available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compds. of high volatility and high thermal stability. TLC-HRMS can be used to monitor chem. reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic org. chem. |
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