| |
[摘要]：The first versatile iodoarene-catalyzed C-C bond-forming reactions were developed using a new reoxidn. system consisting of stoichiometric bis(trifluoroacetyl) peroxide in 2,2,2-trifluoroethanol at low temps. The catalytic system supplies a wide range of substrates and functional availabilities sufficient to be used in the key synthetic process of producing biol. important Amaryllidaceae alkaloids. Thus, a series of spirocyclic benzazepines, e.g. I (R1 = OMe, OCH2Ph, R2 = Br, OMe, R3 = H, OCH2Ph; R1R2 = OCH2O, R2 = H; R4 = F3CCO, Me3COCO), azaanthracenes and carbocyclic analogs was synthesized under these conditions from the corresponding aminoalkyl or aralkyl phenols, e.g. II, in 46-80% yields. |
|
