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[摘要]：Introduction: The nuclear receptors Peroxisome Proliferator-Activated Receptors (PPAR)alpha and PPAR gamma are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively. Evidence is now emerging that the PPAR beta/delta isotype is a potential pharmacological target for the treatment of insulin resistance and type 2 diabetes mellitus. Areas covered: In this review, the capacity of PPAR beta/delta to prevent the development of insulin resistance and type 2 diabetes mellitus is discussed. Special emphasis is placed on preclinical studies and the molecular mechanisms responsible for its actions in the main cell types involved in these pathologies: adipocytes, beta-cells, skeletal muscle cells and hepatocytes. Expert opinion: While several concerns remain for the development of PPAR beta/delta agonists, these drugs have demonstrated their efficacy in the treatment of insulin resistance and type 2 diabetes mellitus in preclinical studies, as well as in a few short clinical studies in humans. Although this data is promising, additional studies must be performed to confirm the efficacy and safety of these drugs in the treatment of type 2 diabetes mellitus. |
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