Asymmetric Conjugate Addition of Grignard Reagents to Pyranones

[摘要]：An efficient enantioselective synthesis of lactones was developed based on the catalytic asymmetric conjugate addition (ACA) of alkyl Grignard reagents to pyranones. The use of 2H-pyran-2-one for the first time in the ACA with Grignard reagents allows for a variety of further transformations to access highly versatile building blocks such as beta-alkyl substituted aldehydes or beta-bromo-gamma-alkyl substituted alcohols with excellent regio- and stereoselectivity.

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