Epoxides to alpha-Mercapto-gamma-lactones via Ionic Liquid Promoted Mercaptoacetylative Ring-Opening-Ring-Closing Cascade

[摘要]：Task-specific ionic liquid promoted {[Bmim]OH} one-pot synthesis of alpha-mercapto-gamma-lactones is reported. The present protocol involves regioselective epoxide ring opening and intramolecular translactonisation cascade. A variety of epoxides undergo this ring-opening-ring-closing cascade with 2-methyl-2-phenyl-1,3-oxathiolan-5-one to afford alpha-mercapto-gamma-lactones diastereoselectively in good to excellent yields. After isolation of the product, the ionic liquid [Bmim]OH could be easily recovered and reused without any loss of efficiency.

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