Synthesis and Structural Verification of the Xylomannan Antifreeze Substance from the Freeze-Tolerant Alaskan Beetle Upis ceramboides

[摘要]：Tetra-, hexa-, and octasaccharide subunits of the [-> 4)-beta-D-Manp-(1 -> 4)-beta-D-Xylp-(1 ->](n) xylomannan motif proposed as the structure of a novel nonprotein, thermal hysteresis-producing antifreeze substance from the freeze-tolerant Alaskan beetle Upis ceramboides have been accessed by total chemical synthesis. Comparison of their NMR spectral data with data of the isolate lends strong support to the proposed structure. Synthetic tetrasaccharides representing various linkage isomers considered (alpha- rather than beta-manno, and linkage through mannose O(3) rather than O(4)) show more significant chemical shift differences with the isolate and are therefore excluded from further consideration.

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