De Novo Synthesis of Benzosceptrin C and Nagelamide H from 7-N-15-Oroidin: Implications for Pyrrole-Aminoimidazole Alkaloid Biosynthesis

[摘要]：De novo synthesis of the natural products benzosceptrin C (7) and nagelamide H (8) was achieved using cell-free enzyme preparations from the marine sponges Agelas sceptrum and Stylissa caribica employing synthetic 7-N-15-oroidin. These, studies provide direct experimental evidence to support the long-standing, but untested, hypothesis that oroidin is a precursor to more complex pyrrole-aminoimidazole alkaloids, such as the sceptrins, benzosceptrins, and nagelamides. In addition, a new nagelamide, didebromonagelamide A (5b), was isolated from S. caribica, representing the first report of a nagelamide-like compound from the Caribbean.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内