Synthesis of Imidazo[1,2-a]pyridines by the Bis(acetyloxy)(phenyl)-lambda(3)-iodane-Mediated Oxidative Coupling of 2-Aminopyridines with beta-Keto Esters and 1,3-Diones

[摘要]：Imidazo[1,2-a]pyridine-3-carboxylates can be prepared directly from 2-aminopyridines and beta-keto esters by using bis(acetyloxy)(phenyl)-lambda(3)-iodane as an oxidant and boron trifluoride etherate as a catalyst. The amount of catalyst plays a key role in determining the course of the reaction. Whereas the use of 0.2 equivalents of catalyst ensures the generation of imidazo[1,2-a]pyridines, raising the amount of catalyst to 1.0 equivalents results in exclusive alpha-acetoxylation of the beta-keto esters. 2-Aminopyridines can also react with 1,3-diones to afford 3-acylimidazo[1,2-a]pyridines.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内