Direct Synthesis of alpha-Amino Amides from N-Alkyl Amines by the Copper-Catalyzed Oxidative Ugi-Type Reaction

[摘要]：alpha-Amino amides can be accessed directly form N-alkyl amines by the isocyanide-compatible oxidative copper-peroxide conditions even in the presence of water. Various functional groups are tolerated in the reaction, leading to the synthesis of various alpha-amino amides in moderate yield. A plausible mechanism is proposed in which an oxidative Ugi-type three-component pathway is supposed to be involved.

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