An Organocatalytic Approach to Enantiopure 2,6-Disubstituted Tetrahydropyranols

[摘要]：A method is described for the synthesis of cis-2,6-disubstituted tetrahydropyranols related to ring A of ambruticin S. An organocatalytic and metal-free aldol condensation was utilized as a key step between appropriate carbonyl-containing precursors resulting in high diastereoselection and 24% overall yield for seven steps.

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