Highly Enantioselective Sequential Hydrogenation of Ethyl 2-Oxo-4-arylbut-3-enoate to Ethyl 2-Hydroxy-4-arylbutyrate.

[摘要]：[NH2Me2]+[{RuCl[(S)-SunPhos]}2(m-Cl3)] gave Et 2-hydroxy-4-arylbutyrate, e.g., I, with 94-96% ee. Further investigation has proved that the hydrogenation proceeded via a sequential hydrogenation of C=O and C=C bonds, which is sensitive to the provided the 2-hydroxy-4-phenylbutyric acid with 81% yield at 99% ee after a single recrystn. from 1,2-dichloroethylene.

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