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SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID: CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON

  作者 INOUE TOHRU; YOKOSHIMA SATOSHI; FUKUYAMA TOHRU  
  选自 期刊  Heterocycles;  卷期  2009年79-1;  页码  373-378  
  关联知识点  
 

[摘要]We have successfully constructed the tetracyclic skeleton of lysergic acid, which features an acylation at the C3 position of the indole as well as an intramolecular Heck reaction. The optically active D ring unit could be derived from L-pyroglutamic acid via a disrotatory electrocyclic reaction of a dibromocyclopropane.

 
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