Organocatalyzed Intramolecular Michael Addition of Morita-Baylis-Hillman Adducts of beta-Arylnitroethylenes: An Entry to 3-Aryl-4-nitrocyclohexanones

[摘要]：The synthesis of 3-aryl-4-nitrocyclohexanones has been achieved from the MoritaBaylisHillman adducts of beta-arylnitroethylenes. The strategy involves proline-catalyzed diastereoselective intramolecular Michael addition to obtain 3,4-trans-disubstituted cyclohexanones. This method provides a facile access to (+/-)-epibatidine analogues.

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