Palladium-Catalyzed Peripheral Arylation of 5-Pyrazolones via Enolizable Bond Protection

[摘要]：Peripheral cross-coupling of the enol form of the 5-pyrazolone scaffold with arylboronic acids promoted by [PdCl2(dppf)] afforded the arylated products in good yields. In this coupling, the protection of the enolizable hydroxyl group of pyrazolone is a prerequisite for ensuring the Suzuki-Miyaura cross-coupling. A particular feature of this process is that it enables the synthesis of 5-hydroxy-3-biphenyl and -terphenylpyrazole derivatives with structural diversity.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内