Regio- and Chemoselective Synthesis of Fully Substituted Furans

[摘要]：Highly functionalized furyl-, indolyl-, and pyrrolylmagnesium reagents are efficiently prepared by direct C-H activation by using regio- and chemoselective magnesium amide bases, such as (tetramethylpiperidyl) magnesium chloride-lithium chloride (TMPMgCl center dot LiCl) or bis(tetramethylpiperidyl)magnesium-bis(lithium chloride) (TMP2Mg center dot 2LiCl), tolerated by a range of sensitive functional groups. These organometallic reagents readily react with various electrophiles, leading to polyfunctional heterocycles. Furthermore, the full functionalization of the sensitive furan scaffold can be achieved.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内