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BF(3)center dot OEt(2)-Catalyzed Unusual Formation of cis-2,3-Disubstituted Tetrahydrofuran Scaffolds

  作者 REDDY B V SUBBA; ANJUM S REHANA; REDDY G MADHUSUDHAN; RAO T PRABHAKAR  
  选自 期刊  SYNLETT;  卷期  2011年-20;  页码  2951-2954  
  关联知识点  
 

[摘要]Aldehydes undergo smooth cyclization with 4-(phenylthio)but-3-en-1-ol in the presence of BF(3)center dot OEt(2) in dichloromethane at room temperature to afford a novel class of 2,3-disubstitued tetrahydrofurans in good yields with all-cis-selectivity. This method is simple, selective, and convenient for the synthesis of tetrahydrofuran scaffolds in a single step.

 
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