Efficient Synthesis of E-alpha-Haloenones Through Chemoselective Alkyne Activation Over Allene with Triazole-Au Catalysts

[摘要]：The E-alpha-haloenones were prepared through a triazole-Au complex (TriA-Au) catalyzed propargyl acetate rearrangement and sequential allene halogenation. The reactions proceeded with only 1% catalyst loading, giving the challenging kinetic products in excellent yields and good to excellent stereoselectivity. These results not only provided the first example for the synthesis of challenging kinetic E-haloenones, but also revealed triazole Au complexes as effective catalysts in promoting chemoselective activation of alkynes over allenes.

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