Synthesis of 8-hydroxyimidazo[1,2-a]pyridine-2-carboxylic acid and its derivatives.

[摘要]：Two imidazo[1,2-a]pyridines, 8-hydroxyimidazo[1,2-a]pyridine-2-carboxylic acid (I, R = OH) and Et 8-hydroxyimidazo[1,2-a]pyridine-2-carboxylate (I, R = OEt) were prepd. via cyclization of 2-aminopyridin-3-ol with bromopyruvic acid and Et bromopyruvate, resp. 8-Hydroxyimidazo[1,2-a]pyridine-2-carboxylic acid (I, R = OH) was successfully coupled with various amino acid derivs. via its active ester intermediate into the corresponding amides. O-protected Et 8-hydroxyimidazo[1,2-a]pyridine-2-carboxylate was transformed into its hydrazide, acyl azide, and amide derivs.

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