SPANphos Ligands in Palladium-Catalyzed Asymmetric Fluorination

[摘要]：The synthesis of new enantiopure wide-bite-angle diphosphanes is described as well as their use in the palladium-catalyzed asymmetric fluorination of a-cyanoacetates. Enantiomeric excesses up to 93?% were obtained when Pd(OAc)2-SPANphos was used as catalyst for the fluorination of ethyl 2-cyano-2-phenylacetate with N-fluorobenzenesulfonimide (NFSI).

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