Ligated Regioselective Pd-II Catalysis to Access beta-Aryl-Bearing Aldehydes, Ketones, and beta-Keto Esters

[摘要]：By employing ligands in the PdII-mediated arylative isomerization of allyl alcohols, a milder and regioselective access to the versatile building blocks beta-aryl aldehydes and ketones was developed. This new and chelation-controlled protocol enabled the compatibility of wide range of functionalities to generate dihydrochalcones, a-benzyl-a'-alkyl acetones, dihydrocinnamaldehydes, and a-benzyl beta-keto esters (from BaylisHillman adducts). A practical multigram synthesis of an intermediate for Propafenone was also demonstrated.

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