Electrophilic Cyclization and Ring-Closing Metathesis as Key Steps in the Synthesis of a 12-Membered Cyclic Enediyne

[摘要]：For the first time, electrophilic cyclization and ring-closing metathesis were used as key steps in the synthesis of a macrocyclic enediyne system, which allowed a 12-membered dienediyne containing a thiophene-fused ring to be obtained. The macrocycle synthesized represents a class of compounds that possess planar chirality and exists in the solid state as two enantiomers, whereas in solution the rate of interconversion is rapid as a result of unhindered switching of the double bond through the macrocycle.

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