【文章名】Preparation of optically active 1-O-alkyl-3-O-arylsulfonyl-sn-glycerol derivatives: substrate engineering in enzyme-mediated enantioselective hydrolysis.
Preparation of optically active 1-O-alkyl-3-O-arylsulfonyl-sn-glycerol derivatives: substrate engineering in enzyme-mediated enantioselective hydrolysis.
[摘要]：Lipase PS catalyzes the enantioselective hydrolysis of various 2-acetyl compds. of 1-O-alkyl-3-O-arylsulfonyl-sn-glycerol derivs. to afford the corresponding optically active compds. Changing the structure of the 1-O-alkyl and 3-O-arylsulfonyl groups affects both the reactivity and enantioselectivity. Finally, the E value of the reaction for 2-acetyl-3-O-(3,5-dimethylbenzenesulfonyl)-1-O-4-(methoxybenzyl)-sn-g lycerol is >200.
