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Microwave-Promoted Solid-Acid-Catalyzed One-Pot Synthesis of Phthalazinones

  作者 OUTERBRIDGE VERONA M; LANDGE SHAINAZ M; TAMAKI HIROKO; TOROK BELA  
  选自 期刊  Synthesis;  卷期  2009年-11;  页码  1801-1806  
  关联知识点  
 

[摘要]A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based oil the direct cyclization of phthalaldehydic acid and opianic acid With substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).

 
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