ASYMMETRIC SYNTHESIS OF (-)-MURICATACIN'S ANALOGUE (4S,5R)-5-HYDROXY-4-OCTADECANOLIDE EXHIBITING THE CYTOTOXICITY AGAINST ESPHAGEAL CANCER CELLS

[摘要]：An efficient and facile synthesis, in six steps and 50% overall yield from commercial D-(-)-lyxose as starting material via twice Wittig olefination and one-pot deisopropylidenation and intramolecular lactonization, of the enantiopure (4S,5R)-(+)-5-hydroxy-4-octadecanolide (2), analogue of (-)-muricatacin, and the cytotoxic activity against CE48T cell line (human esophageal carcinoma) are described and the biological activity is the first shown in the literature.

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