PREPARATION OF D-CYCLOSERINE AND C-13-LABELED D-CYCLOSERINE

[摘要]：D-Cycloserine (DCS), a second stage drug for the treatment of tuberculosis, is synthesized in 19.8% overall yield from DL-serine methyl ester. This synthetic route gives both enantiomers of cycloserine via a corrected and improved one pot resolution procedure using D- and L-tartaric acids. The route is used to synthesize a C-13-labeled derivative for use in biological studies.

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