Direct Catalytic Asymmetric Alkynylation of Ketoimines

[摘要]：An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内