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Tris(azidoethyl)amine Hydrochloride; a Versatile Reagent for Synthesis of Functionalized Dumbbell Oligodeoxynucleotides

  作者 ICHIKAWA SATOSHI; UENO HIDEAKI; SUNADOME TAKUYA; SATO KOUSUKE; MATSUDA AKIRA  
  选自 期刊  Organic Letters;  卷期  2013年15-3;  页码  694-697  
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[摘要]Triazole-cross-linked oligodeoxynucleotides were synthesized using the Cu(I) catalyzed allryne-azide cycloaddition with tris(azidoethyl)amine hydrochloride and oligodeoxynucleotides possessing N-3-(propargyl)thymidine at both the 3'- and 5'-terminl. Further installation of a functional molecule to the dumbbell oligodeoxynucleotides was achieved by utilizing the remaining azide group.

 
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