Relationship between the structures of flavonoids and their NF-kappa B-dependent transcriptional activities

[摘要]：It has been previously shown that some flavonoids inhibit NF-kappa B; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNF alpha induced NF-kappa B inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-kappa B were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-kappa B activation. (C) 2011 Elsevier Ltd. All rights reserved.

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