A SYNTHETIC APPROACH TO DEVELOP PEPTIDE INHIBITORS SELECTIVE FOR BRAIN-TYPE SODIUM CHANNELS ON THE BASIS OF POMPILIDOTOXIN STRUCTURE

[摘要]：To develop inhibitors that are selective for brain-type sodium channels, several peptides were synthesized on the basis of pompilidotoxin structure. A peptide having N-terminal 7 amino acids and its homologs in which Phe(7) is substituted into more hydrophobic amino acids, selectively inhibit sodium current of brain-type sodium channels.

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