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[摘要]：Dynamic kinetic resolution of various alpha-amido-beta-keto phosphonates via asymmetric hydrogenation proceeded efficiently to give the corresponding beta-hydroxy-alpha-amido phosphonates in high diastereo- and enantioselectivities (up to 99:1 syn/anti, 99.8% ee). The addition of catalytic amounts of CeCl3 center dot 7H(2)O is necessary to achieve both good selectivity and catalytic efficiency under mild reaction conditions. |
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