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Continuous Flow Sonogashira C-C Coupling Using a Heterogeneous Palladium-Copper Dual Reactor

  作者 TAN LIMIN; SEM ZHIYU; CHONG WEIYUAN; LIU XIAOQIAN; HENDRA; KWAN WEI LEK; LEE CHILIK KEN  
  选自 期刊  Organic Letters;  卷期  2013年15-1;  页码  65-67  
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[摘要]We report the development of a heterogeneous catalyst system on continuous flow chemistry. A palladium (Pd) coated tubular reactor was placed in line with copper (Cu) tubing using a continuous flow platform, and a Sonogashira C-C coupling reaction was used to evaluate the performance. The reactions were favorably carried out in the Cu reactor, catalyzed by the traces of leached Pd from the Pd reactor. The leached Pd and Cu were trapped with a metal scavaging resin at the back-end of the continuous flow system, affording a genuine approach toward green chemistry.

 
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