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[摘要]：Total syntheses of alpha-galactosyl ceramide, D-ribo-phytosphingosine, and ceramide through an alpha-galactosyl phytosphingosine derivative as a common synthon were accomplished in overall yields of 26%, 15%, and 20% in nine, seven, and eight steps, respectively, starting from an acetonide-protected D-lyxose derivative. This short and efficient protocol involved protection and glycosylation of the acetonide-protected D-lyxose with D-galactosyl iodide as a key step. The resulting alpha-linked disaccharide was subsequently transformed into alpha-galactosyl ceramide, phytosphingosine, and ceramide. |
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