[摘要]:Pd(II)-catalyzed ortho-C H iodination reactions of phenylacetic acid substrates have been achieved using recyclable Pdl(2) as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib. |