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Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials

  作者 Grimberg, BT; Jaworska, MM; Hough, LB; Zimmerman, PA; Phillips, JG  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2009年19-18;  页码  5452-5457  
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[摘要]A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 mu M) overall and ring stage in vitro antimalarial activity. (C) 2009 Elsevier Ltd. All rights reserved.

 
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