Synthesis of 1,1-Disubstituted Olefins via Catalytic Alkyne Hydrothiolation/Kumada Cross-Coupling.

[摘要]：Using recently developed methodol. for the regioselective formation of branched alkyl vinyl sulfides, we report a convenient route to 1,1-disubstituted olefins. We demonstrate that n-propanethiol successfully undergoes catalytic alkyne hydrothiolation with both aryl and aliph. alkynes using Tp*Rh(PPh3)2 as the catalyst. The resulting vinyl sulfides undergo Kumada cross-coupling to afford the desired disubstituted alkene. Both two-step and one-pot procedures are reported.

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