Highly Enantio- and Diastereoselective Synthesis of beta-Methyl-gamma-monofluoromethyl-Substituted Alcohols

[摘要]：Enanatiopure beta-methyl-gamma-monofluoromethyl alcohols were prepared from the allylic alkylation between fluorobis(phenylsulfonyl) methane with Morita-Baylis-Hillman carbonates. The reaction was catalyzed by using the Cinchona alkaloid derivative, (DHQD)(2)AQN. The origin of the stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed stereoselectivity.

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