NEW ENTRY TO THE ASYMMETRIC SYNTHESIS OF (-)-LASUBINE I AND (+)-SUBCOSINE I

[摘要]：A new synthetic entry to (-)-lasubine I and (+)-subcosine I has been established by employing the (S)-allylalkoxy benzylamine as a chiral synthon. The synthesis involves the formation of an alpha,beta-unsaturated lactone by RCM reaction followed by an intramolecular Michael-type addition reaction as a key step, which enables the stereoselective construction of the cis-quinolizidine skeleton of lasubine I and subcosine I.

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