Immunomodulation and the quorum sensing molecule 3-oxo-C-12-homoserine lactone: the importance of chemical scaffolding for probe development

[摘要]：As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C-12-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

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