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A Rapid Three-Component MgI2-Mediated Synthesis of 3,3-Pyrollidinyl Spirooxindoles

  作者 HELAN VICTORIA; MILLS ALLIE; DREWRY DAVID; GRANT DANIEL  
  选自 期刊  Journal of Organic Chemistry;  卷期  2010年75-19;  页码  6693-6695  
  关联知识点  
 

[摘要]The rapid synthesis of 3,3-pyrollidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.

 
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