TOTAL SYNTHESIS OF (+)-HETEROPLEXISOLIDE E

[摘要]：Total synthesis of (+)-heteroplexisolide E has been demonstrated. The synthetic approach exploits the one-pot regioselective Negishi coupling (methylation) and transformation of a beta-methallyl alcohol moiety to a branched prenyl group via palladium-catalyzed hydrogenolysis. For the introduction of the 4-oxo-pentylidene side chain, two independent methods were devised: olefin cross metathesis (CM) (route A) and aldol condensation (route B).

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