Synthesis of functionalized pyroglutamic acids. Part 1: The synthetic utility of N-acylindole and the Ugi reaction with a chiral levulinic acid.

[摘要]：A variety of pyroglutamate derivs. are readily synthesized via N-acylindole intermediates obtained by the Ugi reaction. For the prepn. of functionalized pyroglutamate derivs., the diastereoselectivity of the Ugi 4-center 3-component condensation reaction with a chiral g-keto acid and convertible isocyanide is described.

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